Embelin 2,5-dihydroxy-3-undecyl-1,4-benzoquinone, a chemical component available in dried fruits of Embelia ribes burm F. shows its anthelmintic activity against tapeworms. Embelin is practically insoluble in water. There is a need for solubility enhancement of Embelin in order to enhance its absorption through intestine. The study was aimed to formulate solid dispersions of Embelin by using various carriers (PVP, PVP- K 30, PEG 6000 & PEG 4000) in three different ratios (1:0.5, 1:1 and 1:1.5) using solvent evaporation technique. The prepared solid dispersions were characterized using infrared spectral studies, differential scanning calorimetric studies, aqueous solubility studies, drug content and in-vitro release profile. From FT-IR, XRD, and DSC studies no interaction between Embelin and carrier was observed. Solid dispersion of Embelin with PVP in 1:1 ratio showed maximum enhancement in the solubility of Embelin as well as % drug release after 2 hrs in phosphate buffer pH 7.4. Thus, the solid dispersion technique can be successfully used for improvement of solubility and dissolution profile of Embelin. Successful attempt was made to enhance the solubility of Embelin using solid dispersion technique.
Loading....